Custom Peptides
Cayman Chemical O-desethyl DapaglIflozIn 10mg
An SGLT2 inhibitor (IC50 = 9.4 nM) and active metabolite of dapagliflozin; selective for SGLT2 over SGLT1 (IC50 = 970 nM)
Cayman Chemical ngIotensIn AtrIfluoroACTA 10mg
An AT1 and AT2 receptor agonist and active metabolite of angiotensin II; binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays); induces calcium mobilization in VSMCs (EC50 = 100 nM); increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by EXP-3174; the plasma Ang A/Ang II ratio is increased in patients with end-stage renal failure; serum levels are decreased in patients with pulmonary arterial hypertension
Cayman Chemical 2DeoxyadenosIn5OdIphos 10mg
A nucleotide diphosphate; inhibits the polymerization of ADP and CDP by E. coli or P. fluorescens polynucleotide phosphorylase at 0.23 mM; levels are increased in erythrocytes isolated from patients with adenosine deaminase deficiency and SCID
Cayman Chemical PInoresInol 10mg
A lignan with diverse biological activities; scavenges DPPH and ABTS radicals in cell-free assays (EC50s = 0.2 and 0.055 mg/ml, respectively); selectively inhibits 5-LO and 15-LO over COX-2 (IC50s = 13.8, 3.5, and >100 µM, respectively); inhibits LPS-induced NO production in BV-2 microglial cells (IC50 = 34.25 µM)
Cayman Chemical Batefenterol 10mg
A muscarinic antagonist and β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, and 3.7 nM, for hM2, hM3, and hβ2-AR, respectively); exhibits potent hβ2-AR agonist activity (EC50 = 0.29 nM) with 440- and 320-fold selectivity over hβ1- and hβ3-ARs, respectively; induces smooth muscle relaxation; inhibits bronchoconstrictor response
Cayman Chemical TazarotenIc AcId 10mg
An RAR agonist and an active metabolite of tazarotene; induces reporter gene expression in DK7-NR cells expressing human RARα, RARβ, or RARγ (EC50s = 11, 2.5, and 11 nM, respectively); reduces EAr edema in a PMA-induced mouse model of epidermal inflammation when applied topically at 0.1% w/w
Cayman Chemical SynthetIc Curzeren 10mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical ObtusIfolIn 10mg
An anthraquinone with diverse biological activities; prevents IL-1β-induced increases in NF-κB phosphorylation in chondrocytes at 25-200 µM; reduces cartilage degradation in a mouse model of DMM-induced osteoarthritis at 100 mg/kg; reduces blood glucose levels, as well as serum MDA, NO, triglyceride, and cholesterol levels, and increases serum SOD, GSH, and CAT activity at 30 and 90 mg/kg in a mouse model of STZ-induced diabetes
Cayman Chemical 1PalmItoyl2ArachIdonylsn 10mg
A phospholipid; has been found in egg yolk and isolated rat retina
Cayman Chemical 15hydroxy PentadecNIc ACD 10mg
A hydroxy fatty acid methyl ester; a key intermediate in the synthesis of the musk-odored macrocyclic lactones cyclopentadecanolide and exaltolide
Cayman Chemical DapnsutrIle 10mg
An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS
Cayman Chemical SalbutamolhydrochlorIde 10mg
A β2-AR agonist; induces relaxation of isolated guinea pig tracheal chains (EC50 = 16 nM); selectively binds to the β2-AR over the β1-AR (Kds = 0.236 and 1.54 µM, respectively); nebulized (R)-salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (ED50 = 39.7 μg/animal)
Cayman Chemical ChoArgtrIfluoroACTAte sal 10mg
A steroid-based cationic lipid; forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay; facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum; cytotoxic to H1299 cells (IC50 = 88.5 μg/ml)
Cayman Chemical Endosulfn II 10mg
An organochlorine insecticide; active against a variety of insects including bollworms and tobacco budworms (LD50s = 4.14 and 4.95 mg/g, respectively); binds to GABA receptors (IC50 = 60 nM in rat brain membranes); toxic to rats (LD50 = 240 mg/kg)
Cayman Chemical Grasofermat 10mg
An inhibitor of fatty acid transport; inhibits C1-BODIPY-C12 uptake in HepG2, Caco-2, C2C12, and INS-1E cells (IC50s = 8.1-10.6 μM); prevents palmitate-mediated lipid accumulation and cell death in HepG2 cells and primary hepatocytes; decreases absorption of 13C-oleate in mice at 300 mg/kg